{"id":115,"date":"2020-01-19T15:05:18","date_gmt":"2020-01-19T15:05:18","guid":{"rendered":"https:\/\/aussieuniversity.com\/?p=115"},"modified":"2020-08-13T13:07:49","modified_gmt":"2020-08-13T13:07:49","slug":"your-australian-shepherd-may-be-at-risk","status":"publish","type":"post","link":"https:\/\/aussieuniversity.com\/your-australian-shepherd-may-be-at-risk\/","title":{"rendered":"The MDR 1 Gene Mutation :: Your Australian Shepherd MAY Be At Risk"},"content":{"rendered":"

The MDR 1 Gene Mutation and your Austrailian Shepherd<\/strong><\/h2>\n

We’d like to welcome and thank our guest article writer, Dr. Tatiana da Silva, DVM, for helping to
\nwrite this important article that all owners should be aware of!<\/p>\n

Australian Shepherd owners more than likely have already heard about the
\nMDR1 Gene Mutation. But what exactly is it?\u00a0 Why is it important to know if your
\nAussie is a carrier of that genetic mutation?<\/p>\n

MDR 1 stands for Multi Drug Resistance-1 and its mutation commonly affects<\/strong>
\nmany herding related breeds. Not only can pure breed dogs, but also mixed-<\/strong>
\nbreed dogs can be affected.<\/strong><\/p>\n

It is known that around 50% of Australian Shepherds (mini or standard) carry a
\ngenetic mutation on the MDR-1 Gene that makes them more sensitive to certain
\ntypes of drugs including antibiotics, heartworm preventatives, anesthetics and
\npain control medication, among others.<\/p>\n

\"\"
\nphoto credit ZoeMarieTheAussie<\/a><\/p>\n

Why is the MDR1 Gene Mutation important?<\/strong><\/h2>\n

It is important to know if Aussies carry that mutation because if they do that will
\nimpair their ability to limit the absorption of certain drugs and also slow down
\nthe elimination of these drugs from the body. Basically, they have a higher
\nchance to get intoxicated by these drugs than non-affected dogs. That could
\ncause many severe signs such as disorientation, blindness, tremors and seizures
\nor even, in worse cases, death.<\/p>\n

Ask Your Vet about the MDR1 Gene Mutation<\/strong><\/h2>\n

If your veterinarian is aware that your dog is affected by or is a carrier of this
\nmutation, many precautions will be taken to avoid these symptoms from
\noccurring. For example, your veterinarian will most likely not use certain drugs,
\nor use them in lower dosage. He\/she will also monitor your dog longer in case
\ncertain drugs really need to be used.<\/p>\n

\"\"
\nphoto credit ZoeMarieTheAussie<\/a><\/p>\n

Get your Aussie tested<\/strong><\/h2>\n

But how can you know if your dog is affected by the MDR1 gene mutation?
\nThat is very simple. Just like humans can have DNA test performed, so can your
\ndog. DNA tests will not only show your dog\u2019s genealogic tree, but more
\nimportantly, test them for many genetic diseases, including the MDR1.
\nNow that you are aware of the importance of knowing if your dog is a carrier of
\nthe MDR1 gene mutation, discuss with your veterinarian the best way to find out
\nfor sure so you can provide your Aussie the best care.<\/p>\n

If you want to know more about the MDR1 check out the website from the Washington State University School of Veterinary Medicine<\/strong> (http:\/\/vcpl.vetmed.wsu.edu\/)<\/a> for some useful information.<\/p>\n

If you’d like to see more from Dr. da Silva and her dog Zoe Marie<\/a>, check out there awesome Instagram<\/a> page!<\/p>\n","protected":false},"excerpt":{"rendered":"

The MDR 1 Gene Mutation and your Austrailian Shepherd We’d like to welcome and thank our guest article writer, Dr. Tatiana da Silva, DVM, for helping to write this important<\/p>\n","protected":false},"author":3,"featured_media":119,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"yoast_head":"\nThe MDR 1 Gene Mutation :: Your Australian Shepherd MAY Be At Risk<\/title>\n<meta name=\"description\" content=\"Is your Aussie at Risk? MDR 1 stands for Multi Drug Resistance-1 and its mutation commonly affectsmany herding related breeds. 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